Investigating the mechanical properties of biological brain cells with atomic force microscopy

Bahwini, T, Zhong, Y, Gu, C, Nasa, Z and Oetomo, D 2018, 'Investigating the mechanical properties of biological brain cells with atomic force microscopy', Journal of Medical Devices, vol. 12, no. 4, pp. 1-12.


Document type: Journal Article
Collection: Journal Articles

Title Investigating the mechanical properties of biological brain cells with atomic force microscopy
Author(s) Bahwini, T
Zhong, Y
Gu, C
Nasa, Z
Oetomo, D
Year 2018
Journal name Journal of Medical Devices
Volume number 12
Issue number 4
Start page 1
End page 12
Total pages 12
Publisher The American Society of Mechanical Engineers
Abstract Characterization of cell mechanical properties plays an important role in disease diagnoses and treatments. This paper uses advanced atomic force microscopy (AFM) to measure the geometrical and mechanical properties of two different human brain normal HNC-2 and cancer U87 MG cells. Based on experimental measurement, it measures the cell deformation and indentation force to characterize cell mechanical properties. A fitting algorithm is developed to generate the force-loading curves from experimental data. An inverse Hertzian method is also established to identify Young's moduli for HNC-2 and U87 MG cells. The results demonstrate that Young's modulus of cancer cells is different from that of normal cells, which can help us to differentiate normal and cancer cells from the biomechanical viewpoint. Copyright
Subject Automation and Control Engineering
DOI - identifier 10.1115/1.4040995
Copyright notice © 2019 by ASME
ISSN 1932-6181
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