Therapeutic Cancer Vaccines-T Cell Responses and Epigenetic Modulation

Kartikasari, A, Prakash, M, Cox, M, Wilson, K, Boer, J, Cauchi, J and Plebanski, M 2018, 'Therapeutic Cancer Vaccines-T Cell Responses and Epigenetic Modulation', Frontiers in immunology, vol. 9, pp. 1-15.

Document type: Journal Article
Collection: Journal Articles

Title Therapeutic Cancer Vaccines-T Cell Responses and Epigenetic Modulation
Author(s) Kartikasari, A
Prakash, M
Cox, M
Wilson, K
Boer, J
Cauchi, J
Plebanski, M
Year 2018
Journal name Frontiers in immunology
Volume number 9
Start page 1
End page 15
Total pages 15
Publisher Frontiers Research Foundation
Abstract There is great interest in developing efficient therapeutic cancer vaccines, as this type of therapy allows targeted killing of tumor cells as well as long-lasting immune protection. High levels of tumor-infiltrating CD8(+) T cells are associated with better prognosis in many cancers, and it is expected that new generation vaccines will induce effective production of these cells. Epigenetic mechanisms can promote changes in host immune responses, as well as mediate immune evasion by cancer cells. Here, we focus on epigenetic modifications involved in both vaccine-adjuvant-generated T cell immunity and cancer immune escape mechanisms. We propose that vaccine-adjuvant systems may be utilized to induce beneficial epigenetic modifications and discuss how epigenetic interventions could improve vaccine-based therapies. Additionally, we speculate on how, given the unique nature of individual epigenetic landscapes, epigenetic mapping of cancer progression and specific subsequent immune responses, could be harnessed to tailor therapeutic vaccines to each patient.
Subject Immunology not elsewhere classified
Keyword(s) biomarkers
cancer vaccine-adjuvants
DNA methylation
histone modifications
long non-coding RNAs
T cells
DOI - identifier 10.3389/fimmu.2018.03109
Copyright notice Copyright © 2019 Kartikasari, Prakash, Cox, Wilson, Boer, Cauchi and Plebanski. Creative Commons Attribution License (CC BY).
ISSN 1664-3224
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