Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser

Lomb, L, Barends, T, Kassemeyer, S, Aquila, A and Martin, A., et al., 2011, 'Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser', Physical Review B - Condensed Matter and Materials Physics, vol. 84, no. 21, pp. 1-6.


Document type: Journal Article
Collection: Journal Articles

Title Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser
Author(s) Lomb, L
Barends, T
Kassemeyer, S
Aquila, A
Martin, A., et al.,
Year 2011
Journal name Physical Review B - Condensed Matter and Materials Physics
Volume number 84
Issue number 21
Start page 1
End page 6
Total pages 6
Publisher American Physical Society
Abstract X-ray free-electron lasers deliver intense femtosecond pulses that promise to yield high resolution diffraction data of nanocrystals before the destruction of the sample by radiation damage. Diffraction intensities of lysozyme nanocrystals collected at the Linac Coherent Light Source using 2 keV photons were used for structure determination by molecular replacement and analyzed for radiation damage as a function of pulse length and fluence. Signatures of radiation damage are observed for pulses as short as 70 fs. Parametric scaling used in conventional crystallography does not account for the observed effects.
Subject Condensed Matter Imaging
DOI - identifier 10.1103/PhysRevB.84.214111
Copyright notice © 2011 American Physical Society.
ISSN 1098-0121
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