Flavonols and Flavones - Protecting Against Myocardial Ischemia/Reperfusion Injury by Targeting Protein Kinases

Woodman, O, Chin, K, Thomas, C, Ng, D and May, C 2018, 'Flavonols and Flavones - Protecting Against Myocardial Ischemia/Reperfusion Injury by Targeting Protein Kinases', Current Medicinal Chemistry, vol. 25, no. 34, pp. 4402-4415.


Document type: Journal Article
Collection: Journal Articles

Title Flavonols and Flavones - Protecting Against Myocardial Ischemia/Reperfusion Injury by Targeting Protein Kinases
Author(s) Woodman, O
Chin, K
Thomas, C
Ng, D
May, C
Year 2018
Journal name Current Medicinal Chemistry
Volume number 25
Issue number 34
Start page 4402
End page 4415
Total pages 14
Publisher Bentham Science Publishers
Abstract In acute myocardial infarction (AMI), the first line of treatment is to rapidly restore blood flow to the ischemic myocardium to limit infarct size. It is now well established that though clearly beneficial, the positive outcomes of this intervention are limited by injury in response to the reperfusion itself in addition to the prior ischemia. This process is described as reperfusion injury and is considered to contribute to the arrhythmias, microvascular dysfunction and impaired cardiac contractility that is observed even after the restoration of coronary blood flow. Thus an important, currently unmet, therapeutic challenge is to address the outcomes of this reperfusion injury. In this article, we review the evidence that flavonols and flavones may prove useful in preserving cardiac function after ischemia and reperfusion and consider the possible mechanisms, in particular, the inhibition of kinases, by which they may exert protection.
Subject Pharmacology and Pharmaceutical Sciences not elsewhere classified
Cardiovascular Medicine and Haematology not elsewhere classified
Keyword(s) Antioxidant
Cardioprotection
Flavone
Flavonol
Ischemia-reperfusion
Kinase
Reactive oxygen species
DOI - identifier 10.2174/0929867325666180326161730
Copyright notice © 2018 Bentham Science Publisher
ISSN 0929-8673
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