Intrauterine growth restriction and development of the hippocampus: implications for learning and memory in children and adolescents

Gilchrist, C, Cumberland, A, Walker, D and Tolcos, M 2018, 'Intrauterine growth restriction and development of the hippocampus: implications for learning and memory in children and adolescents', The Lancet Child and Adolescent Health, vol. 2, no. 10, pp. 755-764.


Document type: Journal Article
Collection: Journal Articles

Title Intrauterine growth restriction and development of the hippocampus: implications for learning and memory in children and adolescents
Author(s) Gilchrist, C
Cumberland, A
Walker, D
Tolcos, M
Year 2018
Journal name The Lancet Child and Adolescent Health
Volume number 2
Issue number 10
Start page 755
End page 764
Total pages 10
Publisher Elsevier
Abstract Intrauterine growth restriction (IUGR) is often the result of compromised placental function and suboptimal uteroplacental blood flow. Children born with IUGR have impaired cognitive functioning and specific memory deficits, indicating long-lasting impairments in hippocampal functioning; indeed, hippocampal volume is reduced in infants with IUGR. Animal studies have provided valuable insight into the nature of deficits in hippocampal-dependent functions observed in children born with IUGR; outcomes of experimental IUGR reveal reduced neuron numbers and morphological alterations in the cornu ammonis fields 1 and 3 and dentate gyrus subregions of the hippocampus. However, whether such early and ongoing structural changes in the hippocampus could account for deficits in spatial memory reported in adolescent rats with IUGR is yet to be established. Understanding the association between hippocampal structural and functional alterations in IUGR will aid in the development of interventions to minimise the effect of IUGR on the hippocampus and long-term cognitive outcomes.
Subject Foetal Development and Medicine
Central Nervous System
Keyword(s) Cognitive Neuroscience Perspective
Brain-Development
Prenatal Compromise
Chromatin-Structure
Adult Hippocampus
Fetal Hippocampus
Episodic Memory
Birth-Weight
Long-Term
Retardation
DOI - identifier 10.1016/S2352-4642(18)30245-1
Copyright notice © 2018 Elsevier Ltd. All rights reserved.
ISSN 2352-4642
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Altmetric details:
Access Statistics: 14 Abstract Views  -  Detailed Statistics
Created: Mon, 29 Apr 2019, 13:04:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us