Geographic analysis of motor neuron disease mortality and heavy metals released to rivers in spain

Sanchez-Diaz, G, Escobar, F, Badland, H, Arias-Merino, G, Posada de la Paz, M and Alonso-Ferreira, V 2018, 'Geographic analysis of motor neuron disease mortality and heavy metals released to rivers in spain', International Journal of Environmental Research and Public Health, vol. 15, no. 11, pp. 1-10.


Document type: Journal Article
Collection: Journal Articles

Title Geographic analysis of motor neuron disease mortality and heavy metals released to rivers in spain
Author(s) Sanchez-Diaz, G
Escobar, F
Badland, H
Arias-Merino, G
Posada de la Paz, M
Alonso-Ferreira, V
Year 2018
Journal name International Journal of Environmental Research and Public Health
Volume number 15
Issue number 11
Start page 1
End page 10
Total pages 10
Publisher MDPIAG
Abstract The etiology of motor neuron disease (MND) is still unknown. The aims of this study were to: (1) analyze MND mortality at a fine-grained level; and (2) explore associations of MND and heavy metals released into Spanish river basins. MND deaths were extracted from the Spanish nationwide mortality registry (2007-2016). Standardized mortality ratios (SMRs) for MND were estimated at a municipal level. Sites that emitted quantities of heavy metals above the regulatory thresholds were obtained from the European Pollutant Release and Transfer Register database (2007-2015). The relative risks for non-exposed and exposed municipalities (considering a downstream 20 km river section) by type of heavy metal were analyzed using a log-linear model. SMRs were significantly higher in central and northern municipalities. SMRs were 1.14 (1.10-1.17) higher in areas exposed to heavy metals than in non-exposed areas: 0.95 (0.92-0.96). Considering the different metals, we found the following increased MND death risks in exposed areas: 20.9% higher risk for lead, 20.0% for zinc, 16.7% for arsenic, 15.7% for chromium, 15.4% for cadmium, 12.7% for copper, and 12.4% for mercury. This study provides associations between MND death risk and heavy metals in exposed municipalities. Further studies investigating heavy metal exposure are needed to progress in MND understanding.
Subject Urban Design
Keyword(s) Environmental factors
Geographical analysis
Heavy metals
Motor neuron disease
Population-based mortality
DOI - identifier 10.3390/ijerph15112522
Copyright notice © 2018, MDPIAG. All rights reserved.
ISSN 1661-7827
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