Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration

Chen, P, Wu, Z, Leung, A, Chen, X, Landao-Bassonga, E, Gao, J, Chen, L, Zheng, M, Yao, F, Yang, H, Lidgren, L, Allan, B, Liu, Y, Wang, T and Zheng, M 2018, 'Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration', Biomedical Materials (Bristol), vol. 13, no. 6, pp. 1-11.


Document type: Journal Article
Collection: Journal Articles

Title Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration
Author(s) Chen, P
Wu, Z
Leung, A
Chen, X
Landao-Bassonga, E
Gao, J
Chen, L
Zheng, M
Yao, F
Yang, H
Lidgren, L
Allan, B
Liu, Y
Wang, T
Zheng, M
Year 2018
Journal name Biomedical Materials (Bristol)
Volume number 13
Issue number 6
Start page 1
End page 11
Total pages 11
Publisher Institute of Physics Publishing
Abstract Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering. The optimized AgNP-coated collagen membrane exhibited excellent anti-bacterial effects against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) with limited cellular toxicity. It also displayed effective anti-inflammatory effects by reducing the expression and release of inflammatory cytokines including IL-6 and TNF-alpha. Additionally, AgNP-coated collagen membranes were able to induce osteogenic differentiation of mesenchymal stem cells that guide bone regeneration. These findings demonstrate the potential application of AgNP-coated collagen membranes to prevent infection after bone graft introduction in alveolar ridge reconstruction.
Subject Biomaterials
Keyword(s) anti-bacterial
anti-inflammation
collagen
guide bone regeneration
silver nanoparticles
DOI - identifier 10.1088/1748-605X/aae15b
Copyright notice © 2018 IOP Publishing Ltd
ISSN 1748-6041
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