Nanodiamond/poly-ε-caprolactone nanofibrous scaffold for wound management

Houshyar, S, Kumar, G, Rifai, A, Tran, N, Nayak, R, Shanks, R, Padhye, R, Fox, K and Bhattacharyya, A 2019, 'Nanodiamond/poly-ε-caprolactone nanofibrous scaffold for wound management', Materials Science & Engineering C, vol. 100, pp. 378-387.


Document type: Journal Article
Collection: Journal Articles

Title Nanodiamond/poly-ε-caprolactone nanofibrous scaffold for wound management
Author(s) Houshyar, S
Kumar, G
Rifai, A
Tran, N
Nayak, R
Shanks, R
Padhye, R
Fox, K
Bhattacharyya, A
Year 2019
Journal name Materials Science & Engineering C
Volume number 100
Start page 378
End page 387
Total pages 10
Publisher Elsevier BV
Abstract We describe preparation, characterization and cytocompatibility of nanodiamond (ND) dispersed in poly (ε-caprolactone) (PCL) based nanofibrous scaffold. The results show that this unique scaffold potentially provides essential properties for wound healing by enhancing proliferation of epithelial cells, in addition to restricting the microbial activities. Electrospinning technique was used to fabricate and develop PCL-NDs nanocomposite scaffold. The developed nanocomposites were characterized for morphology, thermal, surface and biological properties. The incorporation of ND into the PCL matrix resulted in better moisture management and higher thermal stability. Transmission electron microscopy images and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy showed existence of ND particles on the surface of the nanofibers. The aggregation of ND particles increased with the increase in their concentration in nanofiber. The developed scaffolds showed no cytotoxicity and, due to improved hydrophilicity, better cellular activities with Chinese hamster ovarian (CHO) cells, 43%, 38% and 22% more cell proliferation for PCL-5% ND for 1, 3- and 7-days incubations in compare with PCL. Furthermore, Staphylococcus aureus (S. aureus) showed significantly less affinity to the scaffold surface with the increase in ND concentration, ~56% less for PCL-5% ND in compare with PCL, indicating that such ND dispersed nanofibrous scaffold maybe asuitable choice for complex wound management.
Subject Nanomaterials
Keyword(s) Nanodiamond
Poly (ε-caprolactone)
Wound management
Antimicrobial
Nanocomposite
DOI - identifier 10.1016/j.msec.2019.02.110
Copyright notice Crown Copyright © 2019 Published by Elsevier B.V. All rights reserved.
ISSN 1873-0191
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