Ischaemic stroke in mice induces lung inflammation but not acute lung injury

Austin, V, Ku, J, Miller, A and Vlahos, R 2019, 'Ischaemic stroke in mice induces lung inflammation but not acute lung injury', Scientific Reports, vol. 9, no. 1, pp. 1-10.


Document type: Journal Article
Collection: Journal Articles

Title Ischaemic stroke in mice induces lung inflammation but not acute lung injury
Author(s) Austin, V
Ku, J
Miller, A
Vlahos, R
Year 2019
Journal name Scientific Reports
Volume number 9
Issue number 1
Start page 1
End page 10
Total pages 10
Publisher Nature
Abstract Stroke is a major cause of death worldwide and ischemic stroke is the most common subtype accounting for approximately 80% of all cases. Pulmonary complications occur in the first few days to weeks following ischemic stroke and are a major contributor to morbidity and mortality. Acute lung injury (ALI) occurs in up to 30% of patients with subarachnoid haemorrhage but the incidence of ALI after ischemic stroke is unclear. As ischemic stroke is the most common subtype of stroke, it is important to understand the development of ALI following the initial ischemic injury to the brain. Therefore, this study investigated whether focal ischemic stroke causes lung inflammation and ALI in mice. Ischemic stroke caused a significant increase in bronchoalveolar lavage fluid (BALF) macrophages and neutrophils and whole lung tissue proinflammatory IL-1 beta mRNA expression but this did not translate into histologically evident ALI. Thus, it appears that lung inflammation, but not ALI, occurs after experimental ischemic stroke in mice. This has significant implications for organ donors as the lungs from patient's dying of ischemic stroke are not severely damaged and could thus be used for transplantation in people awaiting this life-saving therapy.
Subject Respiratory Diseases
Keyword(s) medical complications
brain injury
models
impact
DOI - identifier 10.1038/s41598-019-40392-1
Copyright notice © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License
ISSN 2045-2322
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