Temperature-Controlled Microfluidic System Incorporating Polymer Tubes

Zhu, J, Nguyen, T, Baratchi, S, Thurgood, P, Ghorbani, K and Khoshmanesh, K 2019, 'Temperature-Controlled Microfluidic System Incorporating Polymer Tubes', Analytical Chemistry, vol. 91, no. 3, pp. 2498-2505.


Document type: Journal Article
Collection: Journal Articles

Title Temperature-Controlled Microfluidic System Incorporating Polymer Tubes
Author(s) Zhu, J
Nguyen, T
Baratchi, S
Thurgood, P
Ghorbani, K
Khoshmanesh, K
Year 2019
Journal name Analytical Chemistry
Volume number 91
Issue number 3
Start page 2498
End page 2505
Total pages 8
Publisher American Chemical Society
Abstract Here, we demonstrate a multilayered microfluidic system integrated with commercially available polymer tubes for controlling the temperature of the sample under various static and dynamic conditions. Highly controllable temperature profiles can be produced by modulating the flow rate or inlet temperature of the water passing through the tubes. Customised temperature gradients can be created across the length or width of a channel by mismatching the inlet temperature of the tubes. Temperature cycles can also be produced by repeatedly switching the tubes between hot and cold flasks. Proof-of-concept experiments demonstrate the utility of this system for studying the drug-induced calcium signaling of human monocytes under dynamic thermal conditions. The versatility and simplicity of our system provides opportunities for studying temperature-sensitive chemical, biochemical, and biological samples under various operating conditions.
Subject Analytical Chemistry not elsewhere classified
Keyword(s) Controlled drug delivery
Fluidic devices
Microfluidics
Temperature control
DOI - identifier 10.1021/acs.analchem.8b05365
Copyright notice © 2018 American Chemical Society.
ISSN 0003-2700
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