Conditional microglial depletion in rats leads to reversible anorexia and weight loss by disrupting gustatory circuitry

De Luca, S, Sominsky, L, Soch, A, Wang, H, Ziko, I, Rank, M and Spencer, S 2019, 'Conditional microglial depletion in rats leads to reversible anorexia and weight loss by disrupting gustatory circuitry', Brain, Behavior, and Immunity, vol. 77, pp. 77-91.


Document type: Journal Article
Collection: Journal Articles

Title Conditional microglial depletion in rats leads to reversible anorexia and weight loss by disrupting gustatory circuitry
Author(s) De Luca, S
Sominsky, L
Soch, A
Wang, H
Ziko, I
Rank, M
Spencer, S
Year 2019
Journal name Brain, Behavior, and Immunity
Volume number 77
Start page 77
End page 91
Total pages 15
Publisher Academic Press
Abstract Microglia are highly sensitive to dietary influence, becoming activated acutely and long-term by high fat diet. However, their role in regulating satiety and feeding in healthy individuals remains unclear. Here we show that microglia are essential for the normal regulation of satiety and metabolism in rats. Short-term microglial depletion in a Cx3cr1-Dtr rat led to a dramatic weight loss that was largely accounted for by an acute reduction in food intake. This weight loss and anorexia were not likely due to a sickness response since the rats did not display peripheral or central inflammation, withdrawal, anxiety-like behavior, or nausea-associated pica. Hormonal and hypothalamic anatomical changes were largely compensatory to the suppressed food intake, which occurred in association with disruption of the gustatory circuitry at the paraventricular nucleus of the thalamus. Thus, microglia are important in supporting normal feeding behaviors and weight, and regulating preference for palatable food. Inhibiting this circuitry is able to over-ride strong compensatory drives to eat, providing a potential target for satiety control.
Subject Central Nervous System
Keyword(s) Arcuate nucleus
Cx3cr1-Dtr rat
Energy expenditure
Ghrelin
Hypothalamus
Inflammation
Leptin
Microglia
Neuropeptide Y
Paraventricular thalamic nucleus
Satiety
DOI - identifier 10.1016/j.bbi.2018.12.008
Copyright notice © 2018 Elsevier.
ISSN 0889-1591
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