Investigating the feasibility of implementing steady relative to pulsatile flow in atherosclerosis growth modeling

Gabriel, S, Lu, S, Ding, Y, Feng, Y and Gear, J 2015, 'Investigating the feasibility of implementing steady relative to pulsatile flow in atherosclerosis growth modeling', in C.B. Solnordal, P. Liovic, G.W. Delaney, S.J. Cummins, M.P. Schwarz and P.J. Witt (ed.) Proceedings of the 11th International Conference on CFD in the Minerals and Process Industries, Melbourne, Australia, 7-9 December 2015, pp. 1-6.


Document type: Conference Paper
Collection: Conference Papers

Title Investigating the feasibility of implementing steady relative to pulsatile flow in atherosclerosis growth modeling
Author(s) Gabriel, S
Lu, S
Ding, Y
Feng, Y
Gear, J
Year 2015
Conference name Eleventh International Conference on CFD in the Minerals and Process Industries
Conference location Melbourne, Australia
Conference dates 7-9 December 2015
Proceedings title Proceedings of the 11th International Conference on CFD in the Minerals and Process Industries
Editor(s) C.B. Solnordal, P. Liovic, G.W. Delaney, S.J. Cummins, M.P. Schwarz and P.J. Witt
Publisher CSIRO, Melbourne, Australia
Place of publication Melbourne, Australia
Start page 1
End page 6
Total pages 6
Abstract Atherosclerosis is a cardiovascular disease, characterized by the development of blood flow impeding lesions within arterial walls. The progression of the disease is primarily governed by an inflammatory process, which itself is driven by the transport of multiple biochemical species from the blood flow into the arterial wall. As a dominant driver for mass transport, pulsatile blood flow conforms to timescales considerably smaller than those of atherosclerosis growth. Due to the complexity involved in resolving both time-scales, standard mathematical models for describing the growth and progression of atherosclerosis have thus far ignored flow pulsatility. However, it is now understood that this assumption fails for complex flow-fields. The present study attempts to quantify the extent to which a steady flow may be used in atherosclerosis growth models. Using an idealised arterial bifurcation, both steady-state and pulsatile flows are compared. A simplified atherosclerosis growth model is further implemented on the steady flow, to identify sites predisposed to the emergence of atherosclerosis, and their relative extent to which growth occurs. Through the implementation of a pulsatile-perturbation kinetic energy quotient, it was found that sites which were predisposed to atherosclerosis growth were also incidentally coincident with those which were most disturbed by flow pulsatility.
Subjects Biological Mathematics
Numerical and Computational Mathematics not elsewhere classified
Copyright notice Copyright © 2015 CSIRO Australia , All Rights Reserved
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