Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis

Yu, X, Seow, H, Wang, H, Anthony, D, Bozinovski, S, Lin, L, Ye, J and Vlahos, R 2019, 'Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis', Clinical science (London, England : 1979), vol. 133, no. 4, pp. 551-564.


Document type: Journal Article
Collection: Journal Articles

Title Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis
Author(s) Yu, X
Seow, H
Wang, H
Anthony, D
Bozinovski, S
Lin, L
Ye, J
Vlahos, R
Year 2019
Journal name Clinical science (London, England : 1979)
Volume number 133
Issue number 4
Start page 551
End page 564
Total pages 14
Publisher Portland Press
Abstract Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and will become the third largest cause of death in the world by 2030. It is well established that an exaggerated inflammatory and oxidative stress response to cigarette smoke (CS) leads to, emphysema, small airway fibrosis, mucus hypersecretion, and progressive airflow limitation. Current treatments have limited efficacy in inhibiting chronic inflammation and consequently do not reverse the pathology that initiates and drives the long-term progression of disease. In particular, there are no effective therapeutics that target neutrophilic inflammation in COPD, which is known to cause tissue damage by degranulation of a suite of proteolytic enzymes including neutrophil elastase (NE). Matrine, an alkaloid compound extracted from Sophora flavescens Ait, has well known anti-inflammatory activity. Therefore, the aim of the present study was to investigate whether matrine could inhibit CS-induced lung inflammation in mice. Matrine significantly reduced CS-induced bronchoalveolar lavage fluid (BALF) neutrophilia and NE activity in mice. The reduction in BALF neutrophils in CS-exposed mice by matrine was not due to reductions in pro-neutrophil cytokines/chemokines, but rather matrine's ability to cause apoptosis of neutrophils, which we demonstrated ex vivo Thus, our data suggest that matrine has anti-inflammatory actions that could be of therapeutic potential in treating CS-induced lung inflammation observed in COPD.
Subject Respiratory Diseases
Basic Pharmacology
Keyword(s) apoptosis
chronic obstructive pulmonary disease
cigarette smoke
matrine
neutrophils
DOI - identifier 10.1042/CS20180912
Copyright notice © 2019 The Author(s)
ISSN 1470-8736
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