Phellodendri Cortex: A Phytochemical, Pharmacological, and Pharmacokinetic Review

Sun, Y, Lenon, G and Yang, W 2019, 'Phellodendri Cortex: A Phytochemical, Pharmacological, and Pharmacokinetic Review', Evidence-Based Complementary and Alternative Medicine, vol. 2019, pp. 1-45.


Document type: Journal Article
Collection: Journal Articles

Title Phellodendri Cortex: A Phytochemical, Pharmacological, and Pharmacokinetic Review
Author(s) Sun, Y
Lenon, G
Yang, W
Year 2019
Journal name Evidence-Based Complementary and Alternative Medicine
Volume number 2019
Start page 1
End page 45
Total pages 45
Publisher Hindawi Publishing Corporation
Abstract Background. Phellodendri Cortex (PC) or Huang Bai. According to the scientific database of China Plant Species and Chinese pharmacopeia 2015 edition, PC has two main species which are Phellodendron amurense Rupr (PAR) or Guan Huang bai in Chinese and Phellodendron chinense Schneid (PCS) or Chuan Huang bai in Chinese. The crude drugs of PAR and PCS are also called Phellodendri amurensis cortex (PAC) and Phellodendri chinense cortex (PCC), respectively. The medicinal part of the plant is the dried trunk bark. PC has comprehensive therapeutic effects which include anti-inflammatory, antimicrobial, anticancer, hypotensive, antiarrhythmic, antioxidant, and antipyretic agents. The exact ingredients in PC and its species are not fully summarised. Aim of the Study. This study was designed to review and evaluate the pharmacological actions of compounds and to explore the pharmacokinetic knowledge of PC and its species and to also identify the chemical compound(s) with a potential therapeutic effect on atopic dermatitis. Methods. Huang Bai and its English, botanical, and pharmaceutical names were used as keywords to perform database search in Encyclopaedia of traditional Chinese Medicines, PubMed, EMBASE, MEDLINE, Science Direct, Scopus, Web of Science, and China Network Knowledge Infrastructure. The data selection criteria included all the studies that were related to the phytochemical, pharmacological, and pharmacokinetic perspectives of PC and its species or their active constituents. More importantly, the voucher number has been provided to ensure the genuine bark of PC used as the medicinal part in the studies. Results. 140 compounds were summarized from PC and its species: specifically, 18 compounds from PCC, 44 compounds from PCS, 34 compounds from PAC, and 84 compounds from PAR. Obacunone and obaculactone are probably responsible for antiatopic dermatitis effect. PC and its species possess a broad spectrum of pharmacological actions including anti-inflammatory e
Subject Traditional Chinese Medicine and Treatments
Clinical Pharmacology and Therapeutics
Keyword(s) natural product
traditional medicine
complementary and alternative medicine
herbal medicine
review
DOI - identifier 10.1155/2019/7621929
Copyright notice Copyright © 2019 Yue Sun et al. This is an open access article distributed under https://creativecommons.org/licenses/by/4.0/
ISSN 1741-4288
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