Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke

Evans, M, Lim, R, Kim, H and Selemidis, S., et al, 2018, 'Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke', Stroke, vol. 49, no. 3, pp. 700-709.


Document type: Journal Article
Collection: Journal Articles

Title Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke
Author(s) Evans, M
Lim, R
Kim, H
Selemidis, S., et al,
Year 2018
Journal name Stroke
Volume number 49
Issue number 3
Start page 700
End page 709
Total pages 10
Publisher Lippincott Williams & Wilkins
Abstract Background and Purpose: Human amnion epithelial cells (hAECs) are nonimmunogenic, nontumorigenic, antiinflammatory cells normally discarded with placental tissue. We reasoned that their profile of biological features, wide availability, and the lack of ethical barriers to their use could make these cells useful as a therapy in ischemic stroke. Methods: We tested the efficacy of acute (1.5 hours) or delayed (1-3 days) poststroke intravenous injection of hAECs in 4 established animal models of cerebral ischemia. Animals included young (7-14 weeks) and aged mice (20-22 months) of both sexes, as well as adult marmosets of either sex. Results: We found that hAECs administered 1.5 hours after stroke in mice migrated to the ischemic brain via a CXC chemokine receptor type 4-dependent mechanism and reduced brain inflammation, infarct development, and functional deficits. Furthermore, if hAECs administration was delayed until 1 or 3 days poststroke, long-term functional recovery was still augmented in young and aged mice of both sexes. We also showed proof-of-principle evidence in marmosets that acute intravenous injection of hAECs prevented infarct development from day 1 to day 10 after stroke. Conclusions: Systemic poststroke administration of hAECs elicits marked neuroprotection and facilitates mechanisms of repair and recovery.
Subject Cardiology (incl. Cardiovascular Diseases)
Keyword(s) Brain ischemia
Cerebral infarction
Inflammation
Mice
Stem cells
DOI - identifier 10.1161/STROKEAHA.117.019136
Copyright notice © 2018 American Heart Association
ISSN 0039-2499
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