Hedgehog signaling in the maintenance of cancer stem cells

Cochrane, C, Szczepny, A, Watkins, D and Cain, J 2015, 'Hedgehog signaling in the maintenance of cancer stem cells', Cancers, vol. 7, no. 3, pp. 1554-1585.


Document type: Journal Article
Collection: Journal Articles

Title Hedgehog signaling in the maintenance of cancer stem cells
Author(s) Cochrane, C
Szczepny, A
Watkins, D
Cain, J
Year 2015
Journal name Cancers
Volume number 7
Issue number 3
Start page 1554
End page 1585
Total pages 32
Publisher MDPI AG
Abstract Cancer stem cells (CSCs) represent a rare population of cells with the capacity to self-renew and give rise to heterogeneous cell lineages within a tumour. Whilst the mechanisms underlying the regulation of CSCs are poorly defined, key developmental signaling pathways required for normal stem and progenitor functions have been strongly implicated. Hedgehog (Hh) signaling is an evolutionarily-conserved pathway essential for self-renewal and cell fate determination. Aberrant Hh signaling is associated with the development and progression of various types of cancer and is implicated in multiple aspects of tumourigenesis, including the maintenance of CSCs. Here, we discuss the mounting evidence suggestive of Hh-driven CSCs in the context of haematological malignancies and solid tumours and the novel strategies that hold the potential to block many aspects of the transformation attributed to the CSC phenotype, including chemotherapeutic resistance, relapse and metastasis.
Subject Cancer Cell Biology
Cell Development, Proliferation and Death
Signal Transduction
Keyword(s) Cancer stem cells
Hedgehog signaling
Tumourigenesis
DOI - identifier 10.3390/cancers7030851
Copyright notice © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
ISSN 2072-6694
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