The key role of TNF-TNFR2 interactions in the modulation of allergic inflammation: A review

Ahmad, S, Azid, N, Boer, J, Lim, J, Chen, X, Plebanski, M and Mohamud, R 2018, 'The key role of TNF-TNFR2 interactions in the modulation of allergic inflammation: A review', Frontiers in Immunology, vol. 9, pp. 1-10.


Document type: Journal Article
Collection: Journal Articles

Title The key role of TNF-TNFR2 interactions in the modulation of allergic inflammation: A review
Author(s) Ahmad, S
Azid, N
Boer, J
Lim, J
Chen, X
Plebanski, M
Mohamud, R
Year 2018
Journal name Frontiers in Immunology
Volume number 9
Start page 1
End page 10
Total pages 10
Publisher Frontiers Research Foundation
Abstract Tumor necrosis factor-alpha (TNF) is a pleiotropic cytokine, which is thought to play a major role in the pathogenesis of inflammatory diseases, including allergy. TNF is produced at the early stage of allergen sensitization, and then continues to promote the inflammation cascade in the effector phase of allergic reactions. Consequently, anti-TNF treatment has been proposed as a potential therapeutic option. However, recent studies reveal anti-intuitive effects of TNF in the activation and proliferative expansion of immunosuppressive Tregs, tolerogenic DCs and MDSCs. This immunosuppressive effect of TNF is mediated by TNFR2, which is preferentially expressed by immunosuppressive cells. These findings redefine the role of TNF in allergic reaction, and suggest that targeting TNF-TNFR2 interaction itself may represent a novel strategy in the treatment of allergy. Highlights-Pleiotropic function of TNF in allergy is likely mediated by its two receptors, TNFR1 and TNFR2-Activation by TNFR1 results in the allergic inflammatory responses while TNFR2 plays a role in the immune tolerance to allergens-TNFR2 is preferentially expressed by highly suppressive and replicating Tregs and TNFR2 signaling leads to the activation and proliferation of Tregs-Targeting of TNFR2 to boost Treg activity may represent a novel strategy for treating patients with allergy.
Subject Immunology not elsewhere classified
Keyword(s) Allergy
Regulatory T cells
TNF
TNFR2
Tolerogenic dendritic cells
DOI - identifier 10.3389/fimmu.2018.02572
Copyright notice Copyright © 2018 Ahmad, Azid, Boer, Lim, Chen, Plebanski and Mohamud. Creative Commons Attribution License (CC BY).
ISSN 1664-3224
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