Insights into endotoxin-mediated lung inflammation and future treatment strategies

Chakraborty, A, Boer, J, Selomulya, C, Plebanski, M and Royce, S 2018, 'Insights into endotoxin-mediated lung inflammation and future treatment strategies', Expert Review of Respiratory Medicine, vol. 12, no. 11, pp. 941-955.


Document type: Journal Article
Collection: Journal Articles

Title Insights into endotoxin-mediated lung inflammation and future treatment strategies
Author(s) Chakraborty, A
Boer, J
Selomulya, C
Plebanski, M
Royce, S
Year 2018
Journal name Expert Review of Respiratory Medicine
Volume number 12
Issue number 11
Start page 941
End page 955
Total pages 15
Publisher Taylor & Francis
Abstract Introduction: Airway inflammatory disorders are prevalent diseases in need of better management and new therapeutics. Immunotherapies offer a solution to the problem of corticosteroid resistance. Areas covered: The current review focuses on lipopolysaccharide (Gram-negative bacterial endotoxin)-mediated inflammation in the lung and the animal models used to study related diseases. Endotoxin-induced lung pathology is usually initiated by antigen presenting cells (APC). We will discuss different subsets of APC including lung dendritic cells and macrophages, and their role in responding to endotoxin and environmental challenges. Expert commentary: The pharmacotherapeutic considerations to combat airway inflammation should cost-effectively improve quality of life with sustainable and safe strategies. Selectively targeting APCs in the lung offer the potential for a promising new strategy for the better management and treatment of inflammatory lung disease.
Subject Immunology not elsewhere classified
Keyword(s) Airway inflammation
anti-inflammatories
antigen presenting cells
asthma
COPD
endotoxin
DOI - identifier 10.1080/17476348.2018.1523009
Copyright notice © 2018 Informa UK Limited, trading as Taylor & Francis Group
ISSN 1747-6348
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