Porphyrinic Metal-Organic Framework PCN-224 Nanoparticles for Near-Infrared-Induced Attenuation of Aggregation and Neurotoxicity of Alzheimer's Amyloid-β Peptide

Wang, J, Fan, Y, Tan, Y, Zhao, X, Zhang, F, Cheng, C and Yang, M 2018, 'Porphyrinic Metal-Organic Framework PCN-224 Nanoparticles for Near-Infrared-Induced Attenuation of Aggregation and Neurotoxicity of Alzheimer's Amyloid-β Peptide', ACS Applied Materials and Interfaces, vol. 10, no. 43, pp. 36615-36621.


Document type: Journal Article
Collection: Journal Articles

Title Porphyrinic Metal-Organic Framework PCN-224 Nanoparticles for Near-Infrared-Induced Attenuation of Aggregation and Neurotoxicity of Alzheimer's Amyloid-β Peptide
Author(s) Wang, J
Fan, Y
Tan, Y
Zhao, X
Zhang, F
Cheng, C
Yang, M
Year 2018
Journal name ACS Applied Materials and Interfaces
Volume number 10
Issue number 43
Start page 36615
End page 36621
Total pages 7
Publisher American Chemical Society
Abstract The aberrant aggregation of amyloid-β peptide (Aβ) in the brain has been considered as the major pathological hallmark of Alzheimers diseases (AD). Inhibition of Aβ aggregation is considered as an attractive therapeutic intervention for alleviating amyloid-associated neurotoxicity. Here, we report the near-infrared light (NIR)-induced suppression of Aβ aggregation and reduction of Aβ-induced cytotoxicity via porphyrinic metalorganic framework (MOF) PCN-224 nanoparticles. PCN-224 nanoparticles are hydrothermally synthesized by coordinating tetra-kis(4-carboxyphenyl)porphyrin (TCPP) ligands with zirconium. The PCN-224 nanoparticles show high photo-oxygenation efficiency, good biocompatibility, and high stability. The study reveals that the porphyrinic MOF-based nanoprobe activated by NIR light could successfully inhibit self-assembly of monomeric Aβ into a β-sheet-rich structure. Furthermore, photoexcited PCN-224 nanoparticles also significantly reduce Aβ-induced cytotoxicity under NIR irradiation.
Subject Nanobiotechnology
Keyword(s) Alzheimers disease
amyloid-β
metal−organic framework
PCN-224
phototherapy
DOI - identifier 10.1021/acsami.8b15452
Copyright notice © 2018 American Chemical Society
ISSN 1944-8244
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