Dose enhancement effects by different size of gold nanoparticles under irradiation of megavoltage photon beam

W Abd Rahman, W, Rashid, R, Mahfuzah, M, Dollah, N, Razak, K and Geso, M 2018, 'Dose enhancement effects by different size of gold nanoparticles under irradiation of megavoltage photon beam', Jurnal Sains Nuklear Malaysia, vol. 30, no. 2, pp. 23-29.


Document type: Journal Article
Collection: Journal Articles

Title Dose enhancement effects by different size of gold nanoparticles under irradiation of megavoltage photon beam
Author(s) W Abd Rahman, W
Rashid, R
Mahfuzah, M
Dollah, N
Razak, K
Geso, M
Year 2018
Journal name Jurnal Sains Nuklear Malaysia
Volume number 30
Issue number 2
Start page 23
End page 29
Total pages 7
Publisher Malaysian Nuclear Agency
Abstract Gold nanoparticles (AuNPs) have been extensively investigated as dose enhancement agent to increase the lethal dose to the tumourswhile minimizing dose to the normal tissue. Their intriguing properties and characteristics such as small size and shape provide favorable option in increasing radiotherapy therapeutic efficiency. In this study, the effects of AuNPs size on the dose enhancement effects irradiated under megavoltage photon beams were investigated. The study was conducted in-vitro on HeLa cells using AuNPs of 5 nm and 15 nm sizes. The cells samples were incubated with AuNPs and irradiated with photon beam of energy 6 MV and 10 MV at 100 cm SSD and 10 cm x10 cm field size. Clonogenic assay were performed to observe the dose enhancement effects on cell survival. Dose enhancement factor (DEF) were extrapolated and evaluated from the cell survival curves. The results show that both sizes of AuNPs produce dose enhancement with the larger size AuNPs of 15 nm produce more dose enhancement compare to 5 nm AuNPs for 6 MV photon beam. Dose enhancements were observed for 10 MV photon beams but DEF for both sizes AuNPs shows no differences. In conclusion, larger size AuNPs produce higher dose enhancement compare to small size of AuNPs which conclude that nanoparticles size is important factor that need to be taken into account for AuNPs to be applied in radiotherapy.
Subject Medical Physics
Keyword(s) Dose enhancement
gold nanoparticles
megavoltage photon beam
radiotherapy
Copyright notice © 2018 Authors retain copyright and grant the journal right of first publication with the woCreative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
ISSN 2232-0946
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