Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection

Cheung, K, Sze, D, Chan, K and Leung, P 2018, 'Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection', Immunobiology, vol. 223, no. 43589, pp. 356-364.


Document type: Journal Article
Collection: Journal Articles

Title Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection
Author(s) Cheung, K
Sze, D
Chan, K
Leung, P
Year 2018
Journal name Immunobiology
Volume number 223
Issue number 43589
Start page 356
End page 364
Total pages 9
Publisher Elsevier GmbH - Urban und Fischer
Abstract Caspase-4 physically interacts with caspase-1 and is believed to be a proinflammatory caspase that can induce the inflammatory form of programmed cell death (pyroptosis) and the release of mature interleukin (IL)-1β. However, the function of caspase-4 in dengue virus infection is not yet fully understood. We examined the function of caspase-4 in IL-1β production and pyroptosis during dengue virus serotype-2 (DENV-2) infection in human macrophages. In this study, DENV-2 infection increased IL-1β protein level with activated caspase-4 activity. Using primary macrophages, we observed that caspase-4 induces activation of caspase-1 and secretion of IL-1β in response to DENV-2 infection, without the need for secondary signals to stimulate the assembly of the inflammasome. These findings indicate that the regulation of caspase-1 activity by capsase-4 could represent a unique mechanism. Our data suggest that caspase-4 is upstream of caspase-1 in the pathway that regulates pyroptosis and IL-1β synthesis in macrophages during DENV-2 infection.
Subject Immunology not elsewhere classified
Keyword(s) Pyroptosis
Dengue virus
Caspase-4
Interleukin-1β
Inflammasome
DOI - identifier 10.1016/j.imbio.2017.10.044
Copyright notice © 2017 Elsevier GmbH.
ISSN 0171-2985
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