Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Quinn, K, Fox, A, Harland, K and Russ, B., et al, 2018, 'Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells', Cell Reports, vol. 23, no. 12, pp. 3512-3524.


Document type: Journal Article
Collection: Journal Articles

Title Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells
Author(s) Quinn, K
Fox, A
Harland, K
Russ, B., et al,
Year 2018
Journal name Cell Reports
Volume number 23
Issue number 12
Start page 3512
End page 3524
Total pages 13
Publisher Elsevier
Abstract Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct effects on naive CD8+ T cells to reduce intrinsic functionality, but the precise nature of this defect remains undefined. Aging also causes accumulation of antigen-naive but semi-differentiated "virtual memory" (TVM) cells, but their contribution to age-related functional decline is unclear. Here, we show that TVM cells are poorly proliferative in aged mice and humans, despite being highly proliferative in young individuals, while conventional naive T cells (TN cells) retain proliferative capacity in both aged mice and humans. Adoptive transfer experiments in mice illustrated that naive CD8 T cells can acquire a proliferative defect imposed by the aged environment but age-related proliferative dysfunction could not be rescued by a young environment. Molecular analyses demonstrate that aged TVM cells exhibit a profile consistent with senescence, marking an observation of senescence in an antigenically naive T cell population. CD8 T cell responses decline with age, but virtual memory T (TVM) cells accumulate. Quinn et al. demonstrate that TVM cells lose the ability to proliferate in response to TCR signals, but not IL-15, with increasing age. Aged TVM cells express transcriptional and phenotypic markers of senescence, rather than exhaustion.
Subject Cellular Immunology
Keyword(s) ageing
CD8 T cells
cellular senescence
exhaustion
naive CD8 T cells
T cell dysfunction
virtual memory T cells
DOI - identifier 10.1016/j.celrep.2018.05.057
Copyright notice © 2018 The Author(s)
ISSN 2211-1247
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