Ion-substituted calcium phosphate coatings by physical vapor deposition magnetron sputtering for biomedical applications: A review

Qadir, M, Li, Y and Wen, C 2019, 'Ion-substituted calcium phosphate coatings by physical vapor deposition magnetron sputtering for biomedical applications: A review', Acta Biomaterialia, vol. 89, pp. 14-32.


Document type: Journal Article
Collection: Journal Articles

Title Ion-substituted calcium phosphate coatings by physical vapor deposition magnetron sputtering for biomedical applications: A review
Author(s) Qadir, M
Li, Y
Wen, C
Year 2019
Journal name Acta Biomaterialia
Volume number 89
Start page 14
End page 32
Total pages 19
Publisher Elsevier BV
Abstract Coatings based on ion-substituted calcium phosphate (Ca-P) have attracted great attention in the scientific community over the past decade for the development of biomedical applications. Among such Ca-P based structures, hydroxyapatite (HA) has shown significant influence on cell behaviors including cell proliferation, adhesion, and differentiation. These cell behaviors determine the osseointegration between the implant and host bone and the biocompatibility of implants. This review presents a critical analysis on the physical vapor deposition magnetron sputtering (PVDMS) technique that has been used for ion-substituted Ca-P based coatings on implants materials. The effect of PVDMS processing parameters such as discharge power, bias voltage, deposition time, substrate temperature, and post-heat treatment on the surface properties of ion-substituted Ca-P coatings is elucidated. Moreover, the advantages, short comings and future research directions of Ca-P coatings by PVDMS have been comprehensively analyzed. It is revealed that the topography and surface chemistry of amorphous HA coatings influence the cell behavior, and ion-substituted HA coatings significantly increase cell attachment but may result in a cytotoxic effect that reduces the growth of the cells attached to the coating surface areas. Meanwhile, low-crystalline HA coatings exhibit lower rates of osteogenic cell proliferation as compared to highly crystalline HA coatings developed on Ti based surfaces. PVDMS allows a close reproduction of bioapatite characteristics with high adhesion strength and substitution of therapeutic ions. It can also be used for processing nanostructured Ca-P coatings on polymeric biomaterials and biodegradable metals and alloys with enhanced corrosion resistance and biocompatibility. Statement of Significance: Recent studies have utilized the physical vapor deposition magnetron sputtering (PVDMS) for the deposition of Ca-P and ion-substituted Ca-P thin
Subject Biomaterials
Metals and Alloy Materials
Surface Processes
Keyword(s) Biocompatible coating
Calcium phosphate
Hydroxyapatite coating
PVD magnetron sputtering
DOI - identifier 10.1016/j.actbio.2019.03.006
Copyright notice © 2019 Acta Materialia
ISSN 1742-7061
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