Dielectrophoresis manipulation: versatile lateral and vertical mechanisms

Buyong, M, Kayani, A, Hamzah, A and Majlis, B 2019, 'Dielectrophoresis manipulation: versatile lateral and vertical mechanisms', Biosensors, vol. 9, no. 1, pp. 1-26.

Document type: Journal Article
Collection: Journal Articles

Title Dielectrophoresis manipulation: versatile lateral and vertical mechanisms
Author(s) Buyong, M
Kayani, A
Hamzah, A
Majlis, B
Year 2019
Journal name Biosensors
Volume number 9
Issue number 1
Start page 1
End page 26
Total pages 26
Publisher MDPI AG
Abstract Discussing the topic of the capability of dielectrophoresis (DEP) devices in terms of the selective detection and rapid manipulation of particles based on the DEP force (F-DEP) via contactless methods is challenging in medical research, drug discovery and delivery. Nonetheless, the process of the selective detection and rapid manipulation of particles via contactless DEP based on dielectric particles and the surrounding medium can reduce the effects of major issues, including physical contact with the particles and medium contamination to overcome operational difficulties. In this review, DEP microelectromechanical system (MEMS) microelectrodes with a tapered profile for the selective detection and rapid manipulation of particles were studied and compared with those of conventional designs with a straight-cut profile. The main objective of this manuscript is to review the versatile mechanism of tapered DEP MEMS microelectrodes for the purpose of selective detection and rapid manipulation. Thus, this review provides a versatile filtration mechanism with the potential for a glomerular-based membrane in an artificial kidneys' development solution for implementing engineered particles and cells by lateral attraction as well as vertical repulsion in the development of lab-on-a-chip applications. For tapered DEP MEMS microelectrodes, the scope of this study methodology involved the characterisation of DEP, modelling of the polarisation factor and the dynamic dielectric changes between the particles and medium. Comprehensive discussions are presented on the capability of tapered DEP microelectrodes to drive the selected particles and the simulation, fabrication and testing of the tapered profile. This study revealed an outstanding performance with the capability of producing two regions of high electric field intensity at the bottom and top edges of the side wall of tapered microelectrodes. Observations on particle separation mainly by the lateral attraction force of parti
Subject Functional Materials
Microelectromechanical Systems (MEMS)
Keyword(s) dielectrophoresis
lateral and vertical manipulation
DOI - identifier 10.3390/bios9010030
Copyright notice © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access, Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
ISSN 2079-6374
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