Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice

Du, T, Yang, L, Xu, X and Ye, J., et al, 2019, 'Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice', Journal of Endocrinology, vol. 240, no. 2, pp. 195-214.

Document type: Journal Article
Collection: Journal Articles

Title Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
Author(s) Du, T
Yang, L
Xu, X
Ye, J., et al,
Year 2019
Journal name Journal of Endocrinology
Volume number 240
Issue number 2
Start page 195
End page 214
Total pages 20
Publisher BioScientifica Ltd.
Abstract Vincamine, a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle, is clinically used for the treatment of cardio-cerebrovascular diseases, while also treated as a dietary supplement with nootropic function. Given the neuronal protection of vincamine and the potency of β-cell amelioration in treating type 2 diabetes mellitus (T2DM), we investigated the potential of vincamine in protecting β-cells and ameliorating glucose homeostasis in vitro and in vivo. Interestingly, we found that vincamine could protect INS-832/13 cells function by regulating G-protein-coupled receptor 40 (GPR40)/cAMP/Ca 2+ /IRS2/PI3K/Akt signaling pathway, while increasing glucose-stimulated insulin secretion (GSIS) by modulating GPR40/cAMP/Ca2+/CaMKII pathway, which reveals a novel mechanism underlying GPR40-mediated cell protection and GSIS in INS-832/13 cells. Moreover, administration of vincamine effectively ameliorated glucose homeostasis in either HFD/STZ or db/db type 2 diabetic mice. To our knowledge, our current work might be the first report on vincamine targeting GPR40 and its potential in the treatment of T2DM.
Subject Endocrinology
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Keyword(s) GPR40
Insulin secretion
Type 2 diabetes
Β-cell function
DOI - identifier 10.1530/JOE-18-0432
Copyright notice © 2019 Society for Endocrinology Published by Bioscientifica Ltd.
ISSN 0022-0795
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