Development of a computational fluid dynamics model for mucociliary clearance in the nasal cavity

Shang, Y, Inthavong, K and Tu, J 2019, 'Development of a computational fluid dynamics model for mucociliary clearance in the nasal cavity', Journal of Biomechanics, vol. 85, pp. 74-83.


Document type: Journal Article
Collection: Journal Articles

Title Development of a computational fluid dynamics model for mucociliary clearance in the nasal cavity
Author(s) Shang, Y
Inthavong, K
Tu, J
Year 2019
Journal name Journal of Biomechanics
Volume number 85
Start page 74
End page 83
Total pages 10
Publisher Elsevier
Abstract Intranasal drug delivery has attracted significant attention because of the opportunity to deliver systemic drugs directly to the blood stream. However, the mucociliary clearance poses a challenge in gaining high efficacy of intranasal drug delivery because cilia continuously carry the mucus blanket towards the laryngeal region. To better understand mucus flow behaviour on the human nasal cavity wall, we present computational model development, and evaluation of mucus motion on a realistic nasal cavity model reconstructed from CT-scans. The model development involved two approaches based on the actual nasal cavity geometry namely: (i) unwrapped-surface model in 2D domain and (ii) 3D-shell model. Conservation equations of fluid motion were applied to the domains, where a mucus production source term was used to initiate the mucus motion. The analysis included mucus flow patterns, virtual saccharin tests and quantitative velocity magnitude analysis, which demonstrated that the 3D-shell model results provided better agreement with experimental data. The unwrapped-surface model also suffered from mesh-deformations during the unwrapping stage and this led to higher mucus velocity compared to experimental data. Therefore, the 3D-shell model was recommended for future mucus flow simulations. As a first step towards mucus motion modelling this study provides important information that accurately simulates a mucus velocity field on a human nasal cavity wall, for assessment of toxicology and efficacy of intranasal drug delivery.
Subject Numerical Modelling and Mechanical Characterisation
Keyword(s) CFD
Mucus
Nasal cavity
Surface-unwrapping
DOI - identifier 10.1016/j.jbiomech.2019.01.015
Copyright notice Crown Copyright © 2019 Published by Elsevier B.V. All rights reserved.
ISSN 0021-9290
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