Porous Ti-10Mo alloy fabricated by powder metallurgy for promoting bone regeneration

Xu, W, Liu, Z, Lu, X, Tian, J, Cheng, G, Liu, B, Li, Z, Qu, X and Wen, C 2019, 'Porous Ti-10Mo alloy fabricated by powder metallurgy for promoting bone regeneration', Science China Materials, vol. 62, no. 7, pp. 1053-1064.


Document type: Journal Article
Collection: Journal Articles

Title Porous Ti-10Mo alloy fabricated by powder metallurgy for promoting bone regeneration
Author(s) Xu, W
Liu, Z
Lu, X
Tian, J
Cheng, G
Liu, B
Li, Z
Qu, X
Wen, C
Year 2019
Journal name Science China Materials
Volume number 62
Issue number 7
Start page 1053
End page 1064
Total pages 12
Publisher Science in China Press
Abstract Porous Ti-10Mo alloys were fabricated by powder metallurgy using a space-holder method. The pore characteristics, microstructure, mechanical properties, in vitro biocompatibility, and in vivo osseointegration of the fabricated alloys were systematically investigated. The results show that with different weight ratios of the space-holder (NH 4 HCO 3 ) added, all of the porous Ti-10Mo alloys sintered at 1,300°C exhibited a typical Widmanstätten microstructure. The porosity and average pore size of the porous structures can be controlled in the range of 50.8%66.9% and 70.1381.4 μm, respectively. The Ti-10Mo alloy with 63.4% porosity exhibited the most suitable mechanical properties for implant applications with an elastic modulus of 2.9 GPa and a compressive yield strength of 127.5 MPa. In vitro, the alloyconditioned medium showed no deleterious effect on the cell proliferation. The cell viability in this medium was higher than that of the reference group, suggesting non-toxicity and good biological characteristics of the alloy specimens. In vivo, after eight weeks implantation, new bone tissue formed surrounding the alloy implants, and no noticeable inflammation was observed at the implantation site. The bone bonding strength of the porous Ti-10Mo alloy increased over time from 46.6 N at two weeks to 176.4 N at eight weeks. Suitable mechanical properties together with excellent biocompatibility in vitro and osteointegration in vivo make the porous Ti-10Mo fabricated by powder metallurgy an attractive orthopedic implant alloy.
Subject Biomaterials
Metals and Alloy Materials
Keyword(s) cell cytotoxicity
osteointegration
Porosity
powder metallurgy
structure characterization
DOI - identifier 10.1007/s40843-018-9394-9
Copyright notice © Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019
ISSN 2095-8226
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