Dielectrophoresis for the manipulation of micro/nano particles in microfluidic systems

Zhang, C, Khoshmanesh, K, Mitchell, A and Kalantar Zadeh, K 2010, 'Dielectrophoresis for the manipulation of micro/nano particles in microfluidic systems', Analytical and Bioanalytical Chemistry, vol. 396, no. 1, pp. 401-420.

Document type: Journal Article
Collection: Journal Articles

Title Dielectrophoresis for the manipulation of micro/nano particles in microfluidic systems
Author(s) Zhang, C
Khoshmanesh, K
Mitchell, A
Kalantar Zadeh, K
Year 2010
Journal name Analytical and Bioanalytical Chemistry
Volume number 396
Issue number 1
Start page 401
End page 420
Total pages 20
Publisher Springer
Abstract The manipulation of micro- and nano-particles in fluids is one of the challenges for biological applications of microfluidic systems. In this work a method is developed for the local immobilization of particles collected from relatively large volumes. Micro- or nano-particles suspended in a liquid in microfluidic channels can be manipulated both by electro-osmosis (EO) and by dielectrophoresis (DEP) via the use of metallic electrodes. A positive dielectrophoretic force pulls the particles towards the edges of the electrodes. However, dielectrophoresis is a short-range interaction, hence only the particles in the immediate vicinity can be influenced and fixed. In contrast, electro-osmosis can be used to induce a circulation in the channel and thus exert a long-range interaction. In this approach, electro-osmosis and dielectrophoresis are combined for the manipulation of particles in a fluid cell to immobilize most of the particles distributed in the cell on a test-device. To this effect the fluid is locally circulated in the channel by an electro-osmotic flow which is induced by a voltage applied to a set of electrodes (EO-electrodes). Particles that come close to a second set of electrodes (DEP-electrodes) to which appropriate voltages are applied are influenced by the short-range interaction of the dielectrophoresis, whereby they are captured at these electrodes.
Subject Fluidisation and Fluid Mechanics
Microelectromechanical Systems (MEMS)
Keyword(s) micro-particles
microfluidic systems
DOI - identifier 10.1007/s00216-009-2922-6
Copyright notice © 2009 Springer-Verlag
ISSN 1618-2650
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