Modelling the inhalation of drug particles in a human nasal cavity

Inthavong, K, Wen, J and Tu, J 2010, 'Modelling the inhalation of drug particles in a human nasal cavity', Journal of Biomedical Science and Engineering, vol. 3, no. 1, pp. 52-58.


Document type: Journal Article
Collection: Journal Articles

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Title Modelling the inhalation of drug particles in a human nasal cavity
Author(s) Inthavong, K
Wen, J
Tu, J
Year 2010
Journal name Journal of Biomedical Science and Engineering
Volume number 3
Issue number 1
Start page 52
End page 58
Total pages 7
Publisher Scientific Research Publishing, Inc.
Abstract A human nasal cavity was reconstructed from CT scans to make a Computational Fluid Dynamics (CFD) model. With this model, fluid flow and inhalation of aerosol analysis can be investigated. The surface of the interior nasal cavity is lined with highly vascularised mucosa which provides a means for direct drug delivery into the blood stream. Typical sprayed particles from a nasal spray device produce a particle size distribution with a mean diameter of 50μm, which leads to early deposition due to inertial impaction. In this study low-density drug particles and submicron particles (including nanoparticles) are used to evaluate their deposition patterns. It was found that the low-density particles lightens the particle inertial properties however the particle inertia is more sensitive to the particle size rather than the density. Moreover the deposition pattern for nano-particles is spread out through the airway. Thus an opportunity may exist to develop low-density and nanoparticles to improve the efficiency of drug delivery to target deposition on the highly vascularised mucosal walls. SciRes Copyright © 2010.
Keyword(s) Nasal Airway
Ultrafine
Fibre
Morphology
CFD
Deposition
DOI - identifier 10.4236/jbise.2010.31008
ISSN 1937-6871
Additional Notes Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
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