Biological consequences of statins in Candida species and possible implications for human health

Wikhe, K, Westermeyer, C and Macreadie, I 2007, 'Biological consequences of statins in Candida species and possible implications for human health', Biochemical Society Transactions, vol. 35, pp. 1529-1532.


Document type: Journal Article
Collection: Journal Articles

Title Biological consequences of statins in Candida species and possible implications for human health
Author(s) Wikhe, K
Westermeyer, C
Macreadie, I
Year 2007
Journal name Biochemical Society Transactions
Volume number 35
Start page 1529
End page 1532
Total pages 4
Publisher Portland Press
Abstract The statins, simvastatin and atorvastatin are the most widely prescribed drugs. Statins lower cholesterol levels through their action on HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase, an essential enzyme for the biosynthesis of cholesterol. Fungal HMG-CoA reductases are also inhibited by statins, resulting in reduced levels of ergosterol (the fungal equivalent of cholesterol) and concomitant growth inhibition. This effect occurs in a range of fungal species and possibly affects fungal colonization of people on statin therapy. Furthermore, it may suggest that statins could have a role in new antifungal therapies. Possibly associated with the reduction in ergosterol levels, statins also inhibit respiratory growth. In the yeast, Candida glabrata, passage with statins dramatically increased the frequencies of petite mutants that were devoid of mitochondrial DNA, suggesting that statins caused a defect in the maintenance of mitochondrial DNA. These observations in C. glabrata may provide further insights into side effects of statins in humans undergoing treatment for hypercholesterolemia. In addition, C. glabrata may be highly useful for the preliminary screening of agents to reduce statin side effects.
Keyword(s) Coa Reductase Inhibitors
Saccharomyces-Cerevisiae
Alzheimers-Disease
Coenzyme-Q
In-Vitro
Simvastatin
Cholesterol
Lovastatin
Growth
Yeast
DOI - identifier 10.1042/BST0351529
ISSN 0300-5127
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