CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

Watt, M, Dzanko, N, Thomas, W, Rose-John, S, Ernst, M, Carling, D, Kemp, B, Febbraio, M and Steinberg, G 2006, 'CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK', Nature Medicine, vol. 12, pp. 541-548.


Document type: Journal Article
Collection: Journal Articles

Title CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
Author(s) Watt, M
Dzanko, N
Thomas, W
Rose-John, S
Ernst, M
Carling, D
Kemp, B
Febbraio, M
Steinberg, G
Year 2006
Journal name Nature Medicine
Volume number 12
Start page 541
End page 548
Total pages 8
Publisher Nature Publishing Group
Abstract Ciliary neurotrophic factor (CNTF) induces weight loss and improves glucose tolerance in humans and rodents. CNTF is thought to act centrally by inducing hypothalamic neurogenesis to modulate food intake and peripherally by altering hepatic gene expression, in a manner similar to that of leptin. Here, we show that CNTF signals through the CNTFRa-IL-6R-gp130ß receptor complex to increase fatty-acid oxidation and reduce insulin resistance in skeletal muscle by activating AMP-activated protein kinase (AMPK), independent of signaling through the brain. Thus, our findings further show that the antiobesogenic effects of CNTF in the periphery result from direct effects on skeletal muscle, and that these peripheral effects are not suppressed by diet-induced or genetic models of obesity, an essential requirement for the therapeutic treatment of obesity-related diseases.
Subject Cell Metabolism
Exercise Physiology
Keyword(s) Biochemistry & Molecular Biology
Cell Biology
Medicine
Research & Experimental
DOI - identifier 10.1038/nm1383
ISSN 1078-8956
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