Rapid loss of glutamine synthetase from astrocytes in response to hypoxia: Implications for excitotoxicity

Lee,, Lingwood, B, Bjorkman, S, Miller, S, Poronnik, P, Barnett, N, Colditz, P and Pow, D 2009, 'Rapid loss of glutamine synthetase from astrocytes in response to hypoxia: Implications for excitotoxicity', Journal of Chemical Neuroanatomy, vol. 39, pp. 211-220.


Document type: Journal Article
Collection: Journal Articles

Title Rapid loss of glutamine synthetase from astrocytes in response to hypoxia: Implications for excitotoxicity
Author(s) Lee,
Lingwood, B
Bjorkman, S
Miller, S
Poronnik, P
Barnett, N
Colditz, P
Pow, D
Year 2009
Journal name Journal of Chemical Neuroanatomy
Volume number 39
Start page 211
End page 220
Total pages 10
Publisher Elsevier
Abstract We have examined the brains of neonatal pigs that were rendered hypoxic. Glutamine sythetase (GS), a key enzyme in the detoxification of glutamate and ammonia, was rapidly lost from astrocytes in regions susceptable to damage, including the CA1 of hippocampus and various cortical regions.
Subject Human Biophysics
Keyword(s) Ammonia
Alzheimer's disease
brain
glutamate
stroke
DOI - identifier 10.1016/j.jchemneu.2009.12.002
Copyright notice Elsevier B.V 2009
ISSN 0891-0618
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