Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside

Rivas, D, Yaspelkis, B, Hawley, J and Lessard, S 2009, 'Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside', Journal of Endocrinology, vol. 202, no. 3, pp. 441-451.


Document type: Journal Article
Collection: Journal Articles

Title Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
Author(s) Rivas, D
Yaspelkis, B
Hawley, J
Lessard, S
Year 2009
Journal name Journal of Endocrinology
Volume number 202
Issue number 3
Start page 441
End page 451
Total pages 11
Publisher Society for Endocrinology
Abstract The serine/threonine protein kinase, mammalian target of rapamycin (mTOR) is regulated by insulin and nutrient availability and has been proposed to play a central role as a nutrient sensor in skeletal muscle. mTOR associates with its binding partners, raptor and rictor, to form two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) respectively. We have investigated the assembly of mTORC1/2 and the activation of their downstream substrates (i.e. Akt, S6K1) in response to known effectors of mTOR, excess lipid availability and AMP-activated protein kinase (AMPK) activation/exercise training in rat skeletal muscle. The in vivo formation of mTORC1 and 2 and the activation of their respective downstream substrates were increased in response to chronic (8 weeks) consumption of a high-fat diet. Diet-induced mTORC activation and skeletal muscle insulin
Subject Exercise Physiology
Keyword(s) aminoimidazole carboxamide
AMP-activated protein kinases
animals
blood glucose
carrier proteins
cells
cultured
dietary fats
hypoglycemic agents
insulin
muscle
skeletal
palmitates
phosphorylation
phosphotransferases (alcohol group acceptor)
physical conditioning
animal
proto-oncogene proteins c-akt
rats
rats
Sprague-Dawley
ribonucleotides
transcription factors
tumor suppressor proteins
DOI - identifier 10.1677/JOE-09-0202
Copyright notice © 2009 Society for Endocrinology
ISSN 0022-0795
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