Exercise: It's the real thing!

Hawley, J and Holloszy, J 2009, 'Exercise: It's the real thing!', Nutrition Reviews, vol. 67, no. 3, pp. 172-178.


Document type: Journal Article
Collection: Journal Articles

Title Exercise: It's the real thing!
Author(s) Hawley, J
Holloszy, J
Year 2009
Journal name Nutrition Reviews
Volume number 67
Issue number 3
Start page 172
End page 178
Total pages 7
Publisher International Life Sciences Institute
Abstract The epidemic emergence of modern chronic diseases largely stems from the adoption of a sedentary lifestyle and excess energy intake. However, it has long been known that regular physical activity induces multiple adaptations within skeletal muscle and other organs and these adaptations have positive outcomes for the prevention and treatment of many metabolic disorders. In recognition of such benefits, a recent goal of industry-funded research is to discover orally active compounds that mimic the effects of exercise training, so-called 'exercise pills'. This article provides an overview of the role of skeletal muscle in health and disease and discusses whether 'exercise mimetics' have any potential to combat metabolic diseases.
Keyword(s) AICAR
AMPK
exercise mimetics
obesity
PPARd
skeletal muscle
DOI - identifier 10.1111/j.1753-4887.2009.00185.x
Copyright notice © 2009 International Life Sciences Institute
ISSN 0029-6643
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