mTOR function in skeletal muscle: a focal point for overnutrition and exercise

Rivas, D, Lessard, S and Coffey, V 2009, 'mTOR function in skeletal muscle: a focal point for overnutrition and exercise', Applied Physiology, Nutrition and Metabolism, vol. 34, pp. 807-816.


Document type: Journal Article
Collection: Journal Articles

Title mTOR function in skeletal muscle: a focal point for overnutrition and exercise
Author(s) Rivas, D
Lessard, S
Coffey, V
Year 2009
Journal name Applied Physiology, Nutrition and Metabolism
Volume number 34
Start page 807
End page 816
Total pages 10
Publisher N R C Research Press
Abstract The mammalian target of rapamycin (mTOR) is a highly conserved atypical serine-threonine kinase that controls numerous functions essential for cell homeostasis and adaptation in mammalian cells via 2 distinct protein complex formations. Moreover, mTOR is a key regulatory protein in the insulin signalling cascade and has also been characterized as an insulin-independent nutrient sensor that may represent a critical mediator in obesity-related impairments of insulin action in skeletal muscle. Exercise characterizes a remedial modality that enhances mTOR activity and subsequently promotes beneficial metabolic adaptation in skeletal muscle. Thus, the metabolic effects of nutrients and exercise have the capacity to converge at the mTOR protein complexes and subsequently modify mTOR function. Accordingly, the aim of the present review is to highlight the role of mTOR in the regulation of insulin action in response to overnutrition and the capacity for exercise to enhance mTOR activity in skeletal muscle.
Subject Exercise Physiology
Keyword(s) nutrients
insulin action
metabolism
training
DOI - identifier 10.1139/H09-073
ISSN 1715-5312
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