A regulatory role for CD37 in T cell proliferation

Van Spriel, A, Puls, K, Sofi, M, Pouniotis, D, Plebanski, M and Wright, M 2004, 'A regulatory role for CD37 in T cell proliferation', Journal of Immunology, vol. 175, no. 5, pp. 2953-2961.


Document type: Journal Article
Collection: Journal Articles

Title A regulatory role for CD37 in T cell proliferation
Author(s) Van Spriel, A
Puls, K
Sofi, M
Pouniotis, D
Plebanski, M
Wright, M
Year 2004
Journal name Journal of Immunology
Volume number 175
Issue number 5
Start page 2953
End page 2961
Total pages 9
Publisher American Association of Immunologists
Abstract CD37 is a leukocyte-specific protein belonging to the tetraspanin superfamily. Previously thought to be predominantly a B cell molecule, CD37 is shown in this study to regulate T cell proliferation. CD37-deficient (CD37 -/-) T cells were notably hyperproliferative in MLR, in response to Con A, or CD3-TCR engagement particularly in the absence of CD28 costimulation. Hyperproliferation was not due to differences in memory to naive T cell ratios in CD37-/- mice, apoptosis, or TCR down-modulation. Division cycle analyses revealed CD37-/- T cells to enter first division earlier than wild-type T cells. Importantly, proliferation of CD37-/- T cells was preceded by enhanced early IL-2 production. We hypothesized CD37 to be involved in TCR signaling and this was supported by the observation that CD4/CD8-associated p56Lck kinase activity was increased in CD37 -/- T cells. Remarkably, CD37 cross-linking on human T cells transduced signals that led to complete inhibition of CD3-induced proliferation. In the presence of CD28 costimulation, CD37 engagement still significantly reduced proliferation. Taken together, these results demonstrate a regulatory role for CD37 in T cell proliferation by influencing early events of TCR signaling.
ISSN 0022-1767
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