Schwann cell apoptosis in axotomised sciatic nerve is mediated via NGF through the low affinity neurotrophin receptor

Petratos, S, Butzkueven, H, Shipham, K, Cooper, H, Bucci, T, Reid, K, Lopes, E, Cheema, S and Kilpatrick, T 2003, 'Schwann cell apoptosis in axotomised sciatic nerve is mediated via NGF through the low affinity neurotrophin receptor', Journal of Neuropathology and Experimental Neurology, vol. 62, no. 4, pp. 398-411.


Document type: Journal Article
Collection: Journal Articles

Title Schwann cell apoptosis in axotomised sciatic nerve is mediated via NGF through the low affinity neurotrophin receptor
Author(s) Petratos, S
Butzkueven, H
Shipham, K
Cooper, H
Bucci, T
Reid, K
Lopes, E
Cheema, S
Kilpatrick, T
Year 2003
Journal name Journal of Neuropathology and Experimental Neurology
Volume number 62
Issue number 4
Start page 398
End page 411
Total pages 14
Publisher Lippincott Williams & Wilkins
Abstract Schwann cell death is a developmentally regulated phenomenon and is also induced after peripheral nerve axotomy in neonatal rodents. In this study, we explored whether ligand-induced activation of the low-affinity neurotrophin receptor (p75NTR) is responsible for inducing Schwann cell death in vivo. Administration of exogenous nerve growth factor (NGF) to the axotomized nerve site in wild-type animals resulted in a 2.6-fold increase in Schwann cell apoptosis in the distal nerve stumps compared to axotomy alone. No increase in apoptosis, above baseline levels, was seen in p75NTR-mutant mice either with or without NGF. When anti-NGF antibodies were administered to the site of the peripheral nerve lesion in wild-type mice there was a reduction in the percentage of Schwann cell apoptosis to levels seen in both the quiescent state and in the axotomized nerves of the p75NTR-mutant mice. These results demonstrate that apoptosis of Schwann cells in axotomized peripheral nerve is mediated predominantly through p75NTR signaling and initiated via endogenously produced NGF.
Subject Clinical Sciences not elsewhere classified
Keyword(s) apoptosis
axotomy
low-affinity neurotrophin receptor (p75NTR)
nerve growth factor
Schwann cell
ISSN 0022-3069
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