Distinct patterns of hippocampal formation activity associated with different spatial tasks: A Fos imaging study in rats

Jenkins, T, Amin, E, Harold, G, Pearce, J and Aggleton, J 2003, 'Distinct patterns of hippocampal formation activity associated with different spatial tasks: A Fos imaging study in rats', Experimental Brain Research, vol. 151, no. 4, pp. 514-523.


Document type: Journal Article
Collection: Journal Articles

Title Distinct patterns of hippocampal formation activity associated with different spatial tasks: A Fos imaging study in rats
Author(s) Jenkins, T
Amin, E
Harold, G
Pearce, J
Aggleton, J
Year 2003
Journal name Experimental Brain Research
Volume number 151
Issue number 4
Start page 514
End page 523
Total pages 10
Publisher Springer
Abstract Fos levels were measured in rats trained in one of two qualitatively different spatial memory tasks in a water maze. In one task, (landmark condition) rats found a submerged platform that was always 25 cm south of a visible landmark, the absolute position of the platform and landmark changing after every trial. In the other task (place condition), rats swam to a platform that remained in the same absolute position on every session, but changed session to session, with this task relying on the memory of allocentric cues. Despite matched swim times, the landmark condition resulted in higher levels of Fos in a wide range of cortical and subcortical sites, including the hippocampus and its connections. Structural equation modelling revealed two different patterns of hippocampal function. In the allocentric place task there was a significant association between Fos activity in the entorhinal cortices and the hippocampus proper, while in the non-allocentric landmark task this relationship was not present, but was replaced by a connection from the entorhinal cortices to the subiculum. Thus, the two different tasks engage two different modes of hippocampal activity as demonstrated by Fos expression.
Subject Central Nervous System
Keyword(s) hippocampus
immediate early genes
spatial memory
water maze
DOI - identifier 10.1007/s00221-003-1499-0
ISSN 0014-4819
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