Ischaemia enhances the role of Ca2+-activated K+ channels in endothelium-dependent and nitric oxide-mediated dilatation of the rat hindquarters vasculature

Woodman, O and Wongsawatkul, O 2004, 'Ischaemia enhances the role of Ca2+-activated K+ channels in endothelium-dependent and nitric oxide-mediated dilatation of the rat hindquarters vasculature', Clinical and Experimental Pharmacology and Physiology, vol. 31, no. 4, pp. 254-260.


Document type: Journal Article
Collection: Journal Articles

Title Ischaemia enhances the role of Ca2+-activated K+ channels in endothelium-dependent and nitric oxide-mediated dilatation of the rat hindquarters vasculature
Author(s) Woodman, O
Wongsawatkul, O
Year 2004
Journal name Clinical and Experimental Pharmacology and Physiology
Volume number 31
Issue number 4
Start page 254
End page 260
Total pages 7
Publisher Wiley-Blackwell Publishing Asia
Abstract 1. We compared the effects of the nitric oxide synthase inhibitor N G-nitro-L-arginine (L-NOARG) and tetraethylammonium (TEA), a blocker of large conductance Ca2+-activated K+ (BKCa) channels, on vasodilator responses to endothellum-dependent (acetylcholine; ACh) and -independent (sodium nitroprusside; SNP) vasodilators. The mechanism of the vasodilator responses was determined in rat hindquarters under normal conditions (sham ischaemia) and after 2 h ischaemia followed by reperfusion with physiological saline. 2. In sham ischaemia, the responses to ACh were significantly reduced by L-NOARG (1 mmol/L) and TEA (1 mmol/L) and there was a further reduction in response the presence of both agents. Dilator responses to SNP were significantly enhanced by L-NOARG, whereas TEA did not alter the SNP-induced vasodilatation when given either alone or in the presence of L-NOARG. 3. After ischaemia, L-NOARG caused a similar inhibition of ACh-induced dilatation to that observed in sham ischaemia. However, TEA alone or combined with L-NOARG caused a significantly greater inhibition of the ACh-induced vasodilatation after ischaemia than observed in the sham ischaemia group. Tetraethylammonium alone did not affect the responses to SNP, but it did attenuate the enhanced dilatation observed in the presence of L-NOARG.
Subject Pharmacology and Pharmaceutical Sciences not elsewhere classified
DOI - identifier 10.1111/j.1440-1681.2004.03987.x
ISSN 0305-1870
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