The orexin system regulates alcohol-seeking in rats

Lawrence, A, Cowen, M, Yang, H, Chen, F and Oldfield, B 2006, 'The orexin system regulates alcohol-seeking in rats', British Journal of Pharmacology, vol. 148, no. 6, pp. 752-759.

Document type: Journal Article
Collection: Journal Articles

Title The orexin system regulates alcohol-seeking in rats
Author(s) Lawrence, A
Cowen, M
Yang, H
Chen, F
Oldfield, B
Year 2006
Journal name British Journal of Pharmacology
Volume number 148
Issue number 6
Start page 752
End page 759
Total pages 8
Publisher Nature Publishing Group
Abstract 1. Orexin-containing neurons have been implicated in feeding, sleep-wake cycles and more recently in drug-seeking behaviour. 2. Pretreatment of alcohol-preferring (iP) rats with an orexin1 receptor antagonist (SB-334867, 20 mg kg-1, intraperitoneally) completely abolished an olfactory cue-induced reinstatement of alcohol-seeking behaviour, and also attenuated alcohol responding under an operant fixed ratio regimen without affecting water responding. 3. The mRNA encoding orexin within the hypothalamus was expressed at a similar density in iP and non-preferring (NP) rats; chronic consumption of ethanol in iP rats did not significantly regulate the density of this expression, but did increase the area of expression within the lateral, but not medial, hypothalamus. 4. These data indicate that while orexin may not be implicated in the development of an alcohol preference, re-exposure of cues previously associated with alcohol availability is sufficient and adequate to activate orexin-containing neurons and drive reinstatement of alcohol-seeking.
Subject Central Nervous System
ISSN 0007-1188
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