Neuropeptides: Implications for alcoholism

Cowen, M, Chen, F and Lawrence, A 2004, 'Neuropeptides: Implications for alcoholism', Journal of Neurochemistry, vol. 89, no. 2, pp. 273-285.

Document type: Journal Article
Collection: Journal Articles

Title Neuropeptides: Implications for alcoholism
Author(s) Cowen, M
Chen, F
Lawrence, A
Year 2004
Journal name Journal of Neurochemistry
Volume number 89
Issue number 2
Start page 273
End page 285
Total pages 13
Publisher Wiley-Blackwell Publishing
Abstract The role of neuromodulatory peptides in the aetiology of alcoholism has been relatively under-explored; however, the development of selective ligands for neuropeptide receptors, the characterization and cloning of receptors, and the development of transgenic mouse models have greatly facilitated this analysis. The present review considers the most recent preclinical evidence obtained from animal models for the role of two of the opioid peptides, namely ß-endorphin and enkephalin; corticotropin-releasing factor (CRF), urocortin I and neuropeptide Y (NPY) in deleterious and excessive alcohol consumption, focussing on specific brain regions, in particular the central nucleus of the amygdala, that appear to be implicated in the pathophysiology of alcoholism. The review also outlines potential directions for further research to clarify neuropeptide involvement in neuromodulation within discrete brain nuclei pertinent to behavioural patterns.
DOI - identifier 10.1111/j.1471-4159.2004.02394.x
ISSN 0022-3042
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