St. John's wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats

Hu, Z, Yang, X, Ho, P, Chan, E, Chan, S, XU, C, Li, X, Zhu, Y, Duan, W, Chen, X, Huang, M, Yang, H and Zhou, S 2005, 'St. John's wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats', Pharmaceutical Research, vol. 22, no. 6, pp. 902-914.


Document type: Journal Article
Collection: Journal Articles

Title St. John's wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats
Author(s) Hu, Z
Yang, X
Ho, P
Chan, E
Chan, S
XU, C
Li, X
Zhu, Y
Duan, W
Chen, X
Huang, M
Yang, H
Zhou, S
Year 2005
Journal name Pharmaceutical Research
Volume number 22
Issue number 6
Start page 902
End page 914
Total pages 13
Publisher Springer New York LLC
Abstract Purpose. CPT-11 is a DNA topoisomerase I inhibitor for the therapy of colorectal cancer, whereas St. John's Wort (Hypericum perforatum, SJW) is a widely used herbal anti-depressant. This study aimed to investigate the effects of co-administered SJW on the toxicities and pharmacokinetics of CPT-11 and the underlying mechanisms. Methods. The body weight loss, gastrointestinal and hematological toxicities induced by CPT-11, and the pharmacokinetic parameters of CPT-11 were evaluated in rats pretreated with SJW or vehicle. Results. Rats treated with CPT-11 alone experienced rapid decrease in body weight, whereas co-administration of SJW with CPT-11 resulted in lesser body weight loss. The gastrointestinal and hematological toxicities following CPT-11 injection were both alleviated in the presence of SJW. The rat pharmacokinetics of both CPT-11 and its metabolite SN-38 were significantly altered in presence of SJW. Conclusions. In conclusion, co-administered SJW significantly ameliorated the toxicities induced by CPT-11. The protective effect of SJW may be partially due to pharmacokinetic interaction between CPT-11 and SJW.
Subject Complementary and Alternative Medicine not elsewhere classified
DOI - identifier 10.1007/s11095-005-4585-0
ISSN 0724-8741
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