Ganoderma lucidum polysaccharide fractions accelerate healing of acetic acid-induced ulcers in rats

Gao, Y, Tang, W, Gao, H, Chan, E, Lan, J and Zhou, S 2004, 'Ganoderma lucidum polysaccharide fractions accelerate healing of acetic acid-induced ulcers in rats', Journal of Medicinal Food , vol. 7, no. 4, pp. 417-421.


Document type: Journal Article
Collection: Journal Articles

Title Ganoderma lucidum polysaccharide fractions accelerate healing of acetic acid-induced ulcers in rats
Author(s) Gao, Y
Tang, W
Gao, H
Chan, E
Lan, J
Zhou, S
Year 2004
Journal name Journal of Medicinal Food
Volume number 7
Issue number 4
Start page 417
End page 421
Total pages 5
Publisher Mary Ann Liebert, Inc. Publishers
Abstract The polysaccharide (PS) fractions from several medicinal herbs have been reported to have anti-ulcer effects against experimental ulcers in the rat. The water-soluble PS fractions from Ganoderma lucidum (Reishi mushroom) have been shown to inhibit indomethacin-induced gastric mucosal lesions in rats. This study aimed to investigate the effect of the PS fraction from G. lucidum on the healing of gastric ulcers induced by acetic acid in the rat and to elucidate the underlying mechanisms involved. The abdomen of rats was incised, and the stomach was treated with 10 M acetic acid (100 μL) for 1 minute, and then treated with G. lucidum PS (0.1, 0.5, or 1.0 g/kg) intragastrically, once a day for 14 consecutive days. The results indicated that the oral administration of G. lucidum PS at 0.5 and 1.0 g/kg for 2 weeks caused a significant acceleration of ulcer healing by 40.1% and 55.9%, respectively. In the mechanistic studies, additional rats were treated with 10 M acetic acid to induce acute ulcers, and then treated with G. lucidum PS (1.0 g/kg) for 3, 7, 10, or 14 days. Exposure of the rat stomach to acetic acid led to decreased mucus and increased prostaglandin levels. Treatment with G. lucidum PS at 1.0 g/kg significantly (P < .05) suppressed or restored the decreased gastric mucus levels and increased gastric prostaglandin concentrations compared with the control group. These results indicates that G. lucidum PS is an active component with healing efficacy on acetic acid-induced ulcers in the rat, which may represent a useful herbal preparation for the prevention and treatment of peptic ulcers.
Subject Nutrition and Dietetics not elsewhere classified
Keyword(s) acetic acid
ganoderma lucidum
polysaccharide
reishi mushroom
ulcer
ISSN 1096-620X
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