Gene mutation of thiopurine S-methyltransferase in Uygur Chinese

Zhang, J, Guan, Y, Xu, A, Zhou, S, Wu, J, Wei, H and Huang, M 2004, 'Gene mutation of thiopurine S-methyltransferase in Uygur Chinese', European Journal of Clinical Pharmacology, vol. 60, no. 1, pp. 1-3.


Document type: Journal Article
Collection: Journal Articles

Title Gene mutation of thiopurine S-methyltransferase in Uygur Chinese
Author(s) Zhang, J
Guan, Y
Xu, A
Zhou, S
Wu, J
Wei, H
Huang, M
Year 2004
Journal name European Journal of Clinical Pharmacology
Volume number 60
Issue number 1
Start page 1
End page 3
Total pages 3
Publisher Springer
Abstract Objective: This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese. Methods: Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations - G238C, G460A and A719G. Results: One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively. Conclusion: TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese.
Subject Pharmacogenomics
DOI - identifier 10.1007/s00228-004-0730-7
ISSN 0031-6970
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