Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation

Aung, C, Kruger, W, Poronnik, P, Roberts-Thomson, S and Monteith, G 2007, 'Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation', Biochemical and Biophysical Research Communications, vol. 355, no. 4, pp. 932-936.


Document type: Journal Article
Collection: Journal Articles

Title Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation
Author(s) Aung, C
Kruger, W
Poronnik, P
Roberts-Thomson, S
Monteith, G
Year 2007
Journal name Biochemical and Biophysical Research Communications
Volume number 355
Issue number 4
Start page 932
End page 936
Total pages 5
Publisher Academic Press
Abstract The differentiation of colon cancer cell lines is associated with changes in calcium homeostasis. Concomitantly there are changes in the expression of some calcium transporters and G-protein-coupled receptors, which are capable of altering cytosolic-free calcium levels. Recent studies associate alterations in calcium transporter expression with tumourigenesis, such as changes in specific isoforms of the plasma membrane calcium ATPase (PMCA) in breast cancer cell lines. In this study, we examined the expression of PMCA isoforms in the HT-29 colon cancer cell line using two methods of differentiation (sodium butyrate-mediated and spontaneous post-confluency induced differentiation). Our studies show that differentiation of HT-29 colon cancer cells is associated with the up-regulation of the PMCA isoform PMCA4 but no significant alteration in PMCA1. These results suggest that PMCA4 may be important and have a specific role in colon cells as well as being significant in colon cancer tumourigenesis.
Subject Biochemistry and Cell Biology not elsewhere classified
DOI - identifier 10.1016/j.bbrc.2007.02.050
ISSN 0006-291X
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