Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia

Chen, F, Dworak, M, Wang, Y, Cham, J and Badoer, E 2008, 'Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia', American Journal of Physiology, vol. 295, pp. R1874-R1881.


Document type: Journal Article
Collection: Journal Articles

Title Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia
Author(s) Chen, F
Dworak, M
Wang, Y
Cham, J
Badoer, E
Year 2008
Journal name American Journal of Physiology
Volume number 295
Start page R1874
End page R1881
Total pages 8
Publisher American Physiological Society
Abstract The hypothalamic paraventricular nucleus (PVN) is an important integrative center in the brain. In the present study, we investigated whether the PVN is a key region in the mesenteric vasoconstriction that normally accompanies an increase in core body temperature. Anesthetized rats were monitored for blood pressure, heart rate, mesenteric blood flow, and vascular conductance. In control rats, elevation of core body temperature to 41ºC had no significant effect on blood pressure, increased heart rate, and reduced mesenteric blood flow by 21%. In a separate group of rats, muscimol was microinjected bilaterally (1 nmol/side) into the PVN. Compared with the control group, there was no significant difference in the blood pressure and heart rate responses elicited by the increase in core body temperature. In contrast to control animals, however, mesenteric blood flow did not fall in the muscimol-treated rats in response to the elevation in core body temperature. In a separate group, in which muscimol was microinjected into regions outside the PVN, elevating core body temperature elicited the normal reduction in mesenteric blood flow. The results suggest that the PVN may play a key role in the reflex decrease in mesenteric blood flow elicited by hyperthermia.
Subject Medical Physiology not elsewhere classified
Keyword(s) Increased core body temperature
Reflex mesenteric blood flow
DOI - identifier 10.1152/ajpregu.90384.2008
Copyright notice Copyright © 2008 the American Physiological Society.
ISSN 0363-6119
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