Immunomodulation in endometrial cancer

Brooks, N and Pouniotis, D 2009, 'Immunomodulation in endometrial cancer', International Journal of Gynecological Cancer, vol. 19, no. 4, pp. 734-740.


Document type: Journal Article
Collection: Journal Articles

Title Immunomodulation in endometrial cancer
Author(s) Brooks, N
Pouniotis, D
Year 2009
Journal name International Journal of Gynecological Cancer
Volume number 19
Issue number 4
Start page 734
End page 740
Total pages 7
Publisher Lippincott Williams & Wilkins
Abstract Endometrial cancer is the most frequent gynecological cancer and the fourth most common cancer in women in the developed world. Over the last decade, immunotherapy has been the focus of intense investigation as a form of cancer treatment whereby the treatment initiates a host immune response ultimately eradicating the tumor. It has been suggested that in endometrial cancer and many other forms of cancer, immunosuppression poses a significant obstacle at inducing antitumor immunity by immunotherapy. This review will look at the different studies that have identified immunomodulation of T cells, cytokines and macrophages, and regulation of apoptotic and angiogenic factors in endometrial cancer patients that may contribute to the inefficiency of immunotherapy.
Keyword(s) Endometrial cancer
Immunomodulation
Immunotherapy
DOI - identifier 10.1111/IGC.0b013e3181a12f7f
ISSN 1048-891X
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