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Evidence for coexistence of three Beta-adrenoceptor subtypes in human peripheral lymphocytes Yu, X, Lin, S, Wang, X, Liu, Y, Zhang, B, Lin, Q and Zhou, S 2007, 'Evidence for coexistence of three Beta-adrenoceptor subtypes in human peripheral lymphocytes', Clinical Pharmacology and Therapeutics, vol. 81, no. 5, pp. 654-658. Document type: Journal Article Collection: Journal Articles Title Evidence for coexistence of three Beta-adrenoceptor subtypes in human peripheral lymphocytes Author(s) Yu, X Lin, S Wang, X Liu, Y Zhang, B Lin, Q Zhou, S Year 2007 Journal name Clinical Pharmacology and Therapeutics Volume number 81 Issue number 5 Start page 654 End page 658 Total pages 5 Publisher Nature Publishing Group Abstract Peripheral circulating lymphocytes are easily accessible cells for investigating changes in ß-adrenergic receptors (ADRBs) in humans, but previous reports indicate that these cells only express ADRB2. This study aimed to investigate whether ADRB1 and ADRB3 were expressed in peripheral lymphocytes and the changes of ADRBs in congestive heart failure. Our study demonstrates that ADRB1, ADRB2, and ADRB3 coexist in human peripheral lymphocytes, with differential binding property and expression level. Patients with congestive heart failure had significantly decreased total ADRB density and mRNA levels of ADRB1 and ADRB2 genes, but not ADRB3, compared with healthy subjects. The levels of mRNA of ADRB1 and ADRB2 in peripheral lymphocytes from patients with congestive heart disease were significantly increased after drug treatment. Our study, for the first time, indicates that human peripheral lymphocytes coexpress ADRB1, ADRB2, and ADRB3, which has important implications for precisely predicting clinical response to drug therapy in congestive heart failure. Subject Basic Pharmacology DOI - identifier 10.1038/sj.clpt.6100154 ISSN 0009-9236 Related Links Link Description http://dx.doi.org/10.1038/sj.clpt.6100154 Link to Published Version   Versions Version Filter Type Mon, 06 Dec 2010, 16:50:36 EST Wed, 18 Jun 2014, 00:05:26 EST Filtered Full Citation counts: Cited 19 times in Scopus Article | Citations Altmetric details: Access Statistics: 88 Abstract Views  -  Detailed Statistics Created: Mon, 06 Dec 2010, 14:11:00 EST by Catalyst Administrator