Cell division and apoptosis in the adult neural stem cell niche are differentially affected in transthyretin null mice

Richardson, S, Lemkine, G, Alfama, G, Hassani, Z and Demeneix, B 2007, 'Cell division and apoptosis in the adult neural stem cell niche are differentially affected in transthyretin null mice', Neuroscience Letters, vol. 421, no. 3, pp. 234-238.


Document type: Journal Article
Collection: Journal Articles

Title Cell division and apoptosis in the adult neural stem cell niche are differentially affected in transthyretin null mice
Author(s) Richardson, S
Lemkine, G
Alfama, G
Hassani, Z
Demeneix, B
Year 2007
Journal name Neuroscience Letters
Volume number 421
Issue number 3
Start page 234
End page 238
Total pages 5
Publisher Elsevier Ireland Ltd
Abstract Thyroid hormones (THs) are fundamental in regulation of growth and development, particularly of the brain. THs are required for full proliferative activity of neural stem cells in the subventricular zone (SVZ) of adult mouse brains, and also affect the normal fate of progenitor cells: apoptosis. Transthyretin (TTR) is a TH distributor protein in the blood and cerebrospinal fluid. TTR secretion by the choroid plexus is involved in transport of THs from blood into cerebrospinal fluid. We investigated the regulation of neural stem cell cycle in the SVZ of adult TTR null mice. Markers for neural stem cell mitosis that are reduced during hypothyroidism, did not differ between genotypes. However, in TTR null mice the level of apoptosis, the fate of most progenitor cells, was as low as that in brains of hypothyroid wildtype mice. Thus, lack of TTR results in reduced availability of TH to progenitor cells in the SVZ. We show that proliferation and apoptosis in the SVZ neural stem cell niche are differentially affected by the lack of TTR synthesis.
Subject Neurosciences not elsewhere classified
DOI - identifier 10.1016/j.neulet.2007.05.040
ISSN 0304-3940
Versions
Version Filter Type
Altmetric details:
Access Statistics: 186 Abstract Views  -  Detailed Statistics
Created: Mon, 06 Dec 2010, 14:11:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us