Phytochemical investigation of the Australian lichens Ramalina glaucescens and Xanthoria parietina

Dias, D and Urban, S 2009, 'Phytochemical investigation of the Australian lichens Ramalina glaucescens and Xanthoria parietina', Natural Product Communications, vol. 4, no. 7, pp. 959-964.


Document type: Journal Article
Collection: Journal Articles

Title Phytochemical investigation of the Australian lichens Ramalina glaucescens and Xanthoria parietina
Author(s) Dias, D
Urban, S
Year 2009
Journal name Natural Product Communications
Volume number 4
Issue number 7
Start page 959
End page 964
Total pages 6
Publisher Natural Product Inc.
Abstract Phytochemical investigation of the Australian lichen, Ramalina glaucescens resulted in the isolation of a new halogenated depside, 5-chlorosekikaic acid 5, together with (+)-usnic acid 1, sekikaic acid 2, atranorin 6 and parietin 7, the latter of which was isolated from the associated (co-occurring) lichen, X. parietina. Compound 5 is suspected to be an artifact of the isolation procedure. All structures were assigned using spectroscopic methods and mass spectrometry. In addition to the full characterization of 5, this report represents the first application of 2D NMR spectroscopy to complete the unequivocal chemical shift assignment for compounds 2 and 7. Compounds 1-2 and 5-7 all displayed varying degrees of antitumor activity (ranging from an IC50 of 15 μM to >44 μM) with compounds 1, 2 and 5 also displaying antibacterial properties. Of these, (+)-usnic acid 1 displayed the most significant antitumor and antibacterial activities.
Subject Natural Products Chemistry
Keyword(s) Natural products
Ramalina glaucescens
Xanthoria parietina
sekikaic acid
5-chlorosekikaic acid
atranorin
parietin
(+)-usnic acid
biological activity.
ISSN 1934-578X
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